terguride

Ligand id: 56

Name: terguride

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 47.61
Molecular weight 340.23
XLogP 2.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
α2A-adrenoceptor Antagonist Antagonist 9.5 pKi - 1
pKi 9.5 [1]
α2B-adrenoceptor Antagonist Antagonist 9.4 pKi - 1
pKi 9.4 [1]
α2C-adrenoceptor Antagonist Antagonist 9.1 pKi - 1
pKi 9.1 [1]
D2 receptor Agonist Partial agonist 9.1 pKi - 1
pKi 9.1 [1]
D3 receptor Agonist Partial agonist 9.0 pKi - 1
pKi 9.0 [1]
D2 receptor Antagonist Antagonist 8.9 pKi - 1
pKi 8.9 [1]
5-HT1A receptor Agonist Partial agonist 8.5 pKi - 1
pKi 8.5 [1]
α1A-adrenoceptor Antagonist Antagonist 8.5 pKi - 1
pKi 8.5 [1]
5-HT2A receptor Agonist Partial agonist 8.3 pKi - 1
pKi 8.3 [1]
5-HT2B receptor Antagonist Antagonist 8.2 pKi - 1
pKi 8.2 [1]
D4 receptor Antagonist Antagonist 8.1 pKi - 1
pKi 8.1 [1]
5-HT1D receptor Agonist Partial agonist 7.8 pKi - 1
pKi 7.8 [1]
5-HT2C receptor Antagonist Antagonist 7.3 pKi - 1
pKi 7.3 [1]
5-HT1B receptor Agonist Partial agonist 6.6 pKi - 1
pKi 6.6 [1]