terguride

Ligand id: 56

Name: terguride

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 47.61
Molecular weight 340.23
XLogP 2.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
α2A-adrenoceptor Hs Antagonist Antagonist 9.5 pKi - 1
pKi 9.5 [1]
α2B-adrenoceptor Hs Antagonist Antagonist 9.4 pKi - 1
pKi 9.4 [1]
α2C-adrenoceptor Hs Antagonist Antagonist 9.1 pKi - 1
pKi 9.1 [1]
D2 receptor Hs Agonist Partial agonist 9.1 pKi - 1
pKi 9.1 [1]
D3 receptor Hs Agonist Partial agonist 9.0 pKi - 1
pKi 9.0 [1]
D2 receptor Hs Antagonist Antagonist 8.9 pKi - 1
pKi 8.9 [1]
5-HT1A receptor Hs Agonist Partial agonist 8.5 pKi - 1
pKi 8.5 [1]
α1A-adrenoceptor Hs Antagonist Antagonist 8.5 pKi - 1
pKi 8.5 [1]
5-HT2A receptor Hs Agonist Partial agonist 8.3 pKi - 1
pKi 8.3 [1]
5-HT2B receptor Hs Antagonist Antagonist 8.2 pKi - 1
pKi 8.2 [1]
D4 receptor Hs Antagonist Antagonist 8.1 pKi - 1
pKi 8.1 [1]
5-HT1D receptor Hs Agonist Partial agonist 7.8 pKi - 1
pKi 7.8 [1]
5-HT2C receptor Hs Antagonist Antagonist 7.3 pKi - 1
pKi 7.3 [1]
5-HT1B receptor Hs Agonist Partial agonist 6.6 pKi - 1
pKi 6.6 [1]