AT-7519

Ligand id: 5662

Name: AT-7519

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 98.91
Molecular weight 381.08
XLogP 2.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
cyclin dependent kinase 2 Inhibitor - 7.5 pKd - 1
pKd 7.5 (Kd 3x10-8 M) [1]
cyclin dependent kinase 9 Inhibitor Inhibition >8.0 pIC50 - 2
pIC50 >8.0 (IC50 <1x10-8 M) [2]
cyclin dependent kinase 5 Inhibitor Inhibition 7.9 pIC50 - 2
pIC50 7.9 (IC50 1.3x10-8 M) [2]
cyclin dependent kinase 2 Inhibitor Inhibition 7.3 pIC50 - 2
pIC50 7.3 (IC50 4.7x10-8 M) [2]
cyclin dependent kinase 4 Inhibitor Inhibition 7.0 pIC50 - 2
pIC50 7.0 (IC50 1x10-7 M) [2]
cyclin dependent kinase 6 Inhibitor Inhibition 6.8 pIC50 - 2
pIC50 6.8 (IC50 1.7x10-7 M) [2]
cyclin dependent kinase 1 Inhibitor Inhibition 6.7 pIC50 - 2
pIC50 6.7 (IC50 2.1x10-7 M) [2]