cediranib

Ligand id: 5664

Name: cediranib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 72.5
Molecular weight 450.21
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Cediranib is a potent inhibitor of VEGFR tyrosine kinases and some of the structurally related PDGFR tyrosine kinases, with little or no activity at other kinase family representatives [2].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
kinase insert domain receptor Hs Inhibitor Inhibition 9.0 pKd - 1
pKd 9.0 (Kd 1.1x10-9 M) [1]
kinase insert domain receptor Hs Inhibitor Inhibition >9.0 pIC50 - 2
pIC50 >9.0 (IC50 <1x10-9 M) [2]
KIT proto-oncogene receptor tyrosine kinase Hs Inhibitor Inhibition 8.5 pIC50 - 2
pIC50 8.5 (IC50 3x10-9 M) [2]
fms related tyrosine kinase 4 Hs Inhibitor Inhibition >8.5 pIC50 - 2
pIC50 >8.5 (IC50 <3x10-9 M) [2]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 8.3 pIC50 - 2
pIC50 8.3 (IC50 5x10-9 M) [2]
fms related tyrosine kinase 1 Hs Inhibitor Inhibition 8.3 pIC50 - 2
pIC50 8.3 (IC50 5x10-9 M) [2]
platelet derived growth factor receptor alpha Hs Inhibitor Inhibition 7.4 pIC50 - 2
pIC50 7.4 (IC50 3.6x10-8 M) [2]
colony stimulating factor 1 receptor Hs Inhibitor Inhibition 7.0 pIC50 - 2
pIC50 7.0 (IC50 1.1x10-7 M) [2]
fms related tyrosine kinase 3 Hs Inhibitor Inhibition <6.0 pIC50 - 2
pIC50 <6.0 (IC50 >1x10-6 M) [2]