cediranib

Ligand id: 5664

Name: cediranib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 72.5
Molecular weight 450.21
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Cediranib is a potent inhibitor of VEGFR tyrosine kinases and some of the structurally related PDGFR tyrosine kinases, with little or no activity at other kinase family representatives [2].
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
kinase insert domain receptor Inhibitor Inhibition 9.0 pKd - 1
pKd 9.0 (Kd 1.1x10-9 M) [1]
kinase insert domain receptor Inhibitor Inhibition >9.0 pIC50 - 2
pIC50 >9.0 (IC50 <1x10-9 M) [2]
KIT proto-oncogene receptor tyrosine kinase Inhibitor Inhibition 8.5 pIC50 - 2
pIC50 8.5 (IC50 3x10-9 M) [2]
fms related tyrosine kinase 4 Inhibitor Inhibition >8.5 pIC50 - 2
pIC50 >8.5 (IC50 <3x10-9 M) [2]
platelet derived growth factor receptor beta Inhibitor Inhibition 8.3 pIC50 - 2
pIC50 8.3 (IC50 5x10-9 M) [2]
fms related tyrosine kinase 1 Inhibitor Inhibition 8.3 pIC50 - 2
pIC50 8.3 (IC50 5x10-9 M) [2]
platelet derived growth factor receptor alpha Inhibitor Inhibition 7.4 pIC50 - 2
pIC50 7.4 (IC50 3.6x10-8 M) [2]
colony stimulating factor 1 receptor Inhibitor Inhibition 7.0 pIC50 - 2
pIC50 7.0 (IC50 1.1x10-7 M) [2]
fms related tyrosine kinase 3 Inhibitor Inhibition <6.0 pIC50 - 2
pIC50 <6.0 (IC50 >1x10-6 M) [2]