lapatinib

Ligand id: 5692

Name: lapatinib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 114.73
Molecular weight 580.13
XLogP 6.04
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
erb-b2 receptor tyrosine kinase 2 Inhibitor Inhibition 8.1 pKd - 2
pKd 8.1 (Kd 7x10-9 M) [2]
epidermal growth factor receptor Inhibitor Inhibition 8.0 pIC50 - 4
pIC50 8.0 (IC50 1.02x10-8 M) [4]
erb-b2 receptor tyrosine kinase 2 Inhibitor Inhibition 8.0 pIC50 - 4
pIC50 8.0 (IC50 9.8x10-9 M) [4]