pazopanib

Ligand id: 5698

Name: pazopanib

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: pazopanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 127.41
Molecular weight 437.16
XLogP 2.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
kinase insert domain receptor Inhibitor Inhibition 7.8 pKd - 2
pKd 7.8 (Kd 1.4x10-8 M) [2]
fms related tyrosine kinase 1 Inhibitor Inhibition 8.0 pIC50 - 4
pIC50 8.0 (IC50 1x10-8 M) [4]
kinase insert domain receptor Inhibitor Inhibition 7.5 pIC50 - 4
pIC50 7.5 (IC50 3x10-8 M) [4]
fms related tyrosine kinase 4 Inhibitor Inhibition 7.3 pIC50 - 4
pIC50 7.3 (IC50 4.7x10-8 M) [4]
fibroblast growth factor receptor 1 Inhibitor Inhibition 7.1 pIC50 - 4
pIC50 7.1 (IC50 7.4x10-8 M) [4]
platelet derived growth factor receptor beta Inhibitor Inhibition 7.1 pIC50 - 4
pIC50 7.1 (IC50 8.4x10-8 M) [4]
KIT proto-oncogene receptor tyrosine kinase Inhibitor Inhibition 6.8 pIC50 - 4
pIC50 6.8 (IC50 1.4x10-7 M) [4]
colony stimulating factor 1 receptor Inhibitor Inhibition 6.8 pIC50 - 4
pIC50 6.8 (IC50 1.46x10-7 M) [4]