AZD2624

Ligand id: 5775

Name: AZD2624

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 96.54
Molecular weight 459.16
XLogP 5.82
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Pending any eventual primary medicinal chemistry publication from AstraZeneca the in vitro data presented here was derived from the compound's record in AstaZeneca's Open Innovation Pharmacology Toolbox. However, the record has since been withdrawn.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
NK3 receptor Hs Antagonist Antagonist 8.7 pKi - 1
pKi 8.7 (Ki 2x10-9 M) [1]