Ligand id: 5822

Name: DG-041

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 104.79
Molecular weight 589.93
XLogP 5.61
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
EP3 receptor Hs Antagonist Antagonist 8.4 – 10.1 pKi - 1-2
pKi 10.1 (Ki 8x10-11 M) EP3-I isoform [2]
pKi 9.9 (Ki 1.2x10-10 M) EP3-II isoform [2]
pKi 9.5 (Ki 3x10-10 M) EP3-III isoform [2]
pKi 8.4 (Ki 3.9x10-9 M) [1]