irbesartan

Ligand id: 589

Name: irbesartan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 87.13
Molecular weight 428.23
XLogP 7.21
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
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Target Type Action Affinity Units Concentration range (M) Reference
AT1 receptor Antagonist Antagonist 8.7 – 8.8 pIC50 - 2
pIC50 8.7 – 8.8 (IC50 1.99x10-9 – 1.58x10-9 M) [2]
Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Sodium/bile acid and sulphated solute cotransporter 1 Inhibitor Inhibition 4.9 pKi - 1
pKi 4.9 (Ki 1.19x10-5 M) [1]