ziprasidone

Ligand id: 59

Name: ziprasidone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 76.71
Molecular weight 412.11
XLogP 3.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT2A receptor Hs Antagonist Antagonist 8.8 – 9.5 pKi - 4-5,8-9
pKi 8.8 – 9.5 [4-5,8-9]
5-HT1D receptor Hs Agonist Full agonist 9.0 pKi - 8
pKi 9.0 [8]
D2 receptor Hs Antagonist Antagonist 8.6 pKi - 2
pKi 8.6 (Ki 2.8x10-9 M) [2]
5-HT2C receptor Hs Antagonist Inverse agonist 7.9 – 9.0 pKi - 3,5,9
pKi 7.9 – 9.0 [3,5,9]
5-HT1A receptor Hs Agonist Partial agonist 7.9 – 8.9 pKi - 6,8
pKi 7.9 – 8.9 [6,8]
5-HT7 receptor Hs Antagonist Inverse agonist 8.4 pKi - 7
pKi 8.4 [7]
5-HT1B receptor Hs Agonist Full agonist 8.3 pKi - 8
pKi 8.3 [8]
H1 receptor Hs Antagonist Antagonist 7.4 – 7.8 pKi - 5,8
pKi 7.4 – 7.8 [5,8]
5-ht1e receptor Hs Agonist Full agonist 6.4 pKi - 8
pKi 6.4 [8]
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
NET Rn Inhibitor Inhibition 7.3 pKi - 1
pKi 7.3 (Ki 4.8x10-8 M) [1]
SERT Hs Inhibitor Inhibition 7.3 pKi -
pKi 7.3 (Ki 5.3x10-8 M)