ziprasidone

Ligand id: 59

Name: ziprasidone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 76.71
Molecular weight 412.11
XLogP 3.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT2A receptor Antagonist Antagonist 8.8 – 9.5 pKi - 4-5,8-9
pKi 8.8 – 9.5 [4-5,8-9]
5-HT1D receptor Agonist Full agonist 9.0 pKi - 8
pKi 9.0 [8]
D2 receptor Antagonist Antagonist 8.6 pKi - 2
pKi 8.6 (Ki 2.8x10-9 M) [2]
5-HT2C receptor Antagonist Inverse agonist 7.9 – 9.0 pKi - 3,5,9
pKi 7.9 – 9.0 [3,5,9]
5-HT1A receptor Agonist Partial agonist 7.9 – 8.9 pKi - 6,8
pKi 7.9 – 8.9 [6,8]
5-HT7 receptor Antagonist Inverse agonist 8.4 pKi - 7
pKi 8.4 [7]
5-HT1B receptor Agonist Full agonist 8.3 pKi - 8
pKi 8.3 [8]
H1 receptor Antagonist Antagonist 7.4 – 7.8 pKi - 5,8
pKi 7.4 – 7.8 [5,8]
5-ht1e receptor Agonist Full agonist 6.4 pKi - 8
pKi 6.4 [8]
Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
SERT Inhibitor Inhibition 7.3 pKi -
pKi 7.3 (Ki 5.3x10-8 M)
Selectivity at rat transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
NET Inhibitor Inhibition 7.3 pKi - 1
pKi 7.3 (Ki 4.8x10-8 M) [1]