ATM/ATR kinase inhibitor

Ligand id: 5929

Name: ATM/ATR kinase inhibitor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 128.39
Molecular weight 554.01
XLogP 10.17
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
ATM serine/threonine kinase Inhibitor Inhibition 6.7 pIC50 - 3
pIC50 6.7 (IC50 2x10-7 M) [3]
ATR serine/threonine kinase Inhibitor Inhibition 6.7 pIC50 - 3
pIC50 6.7 (IC50 2x10-7 M) [3]