nintedanib

Ligand id: 5936

Name: nintedanib

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: nintedanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 94.22
Molecular weight 539.25
XLogP 4.97
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Nintedanib is active in vivo, its effects observed as decreased vessel density and integrity and significant growth inhibition [2]. Nintedanib is rapidly metabolised to BIBF-1202 [4].
We have tagged FLT4 (VEGFR-3) as this drug's primary molecular target for data metrics purposes only. We fully acknowledge the multi-targeted nature of nintedanib and include reported kinase interactions in the table below.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
fms related tyrosine kinase 4 Hs Inhibitor Inhibition 7.9 pIC50 - 2
pIC50 7.9 (IC50 1.3x10-8 M) [2]
kinase insert domain receptor Hs Inhibitor Inhibition 7.7 pIC50 - 2
pIC50 7.7 (IC50 2.1x10-8 M) [2]
fms related tyrosine kinase 1 Hs Inhibitor Inhibition 7.5 pIC50 - 2
pIC50 7.5 (IC50 3.1x10-8 M) [2]
fibroblast growth factor receptor 2 Hs Inhibitor Inhibition 7.4 pIC50 - 2
pIC50 7.4 (IC50 3.7x10-8 M) [2]
platelet derived growth factor receptor alpha Hs Inhibitor Inhibition 7.2 pIC50 - 2
pIC50 7.2 (IC50 5.9x10-8 M) [2]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 7.2 pIC50 - 2
pIC50 7.2 (IC50 6.5x10-8 M) [2]
fibroblast growth factor receptor 1 Hs Inhibitor Inhibition 7.2 pIC50 - 2
pIC50 7.2 (IC50 6.9x10-8 M) [2]
fibroblast growth factor receptor 3 Hs Inhibitor Inhibition 7.0 pIC50 - 2
pIC50 7.0 (IC50 1.08x10-7 M) [2]
fibroblast growth factor receptor 4 Hs Inhibitor Inhibition 6.2 pIC50 - 2
pIC50 6.2 (IC50 6.1x10-7 M) [2]