Cdk1/5 inhibitor

Ligand id: 5947

Name: Cdk1/5 inhibitor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 80.48
Molecular weight 185.07
XLogP 1.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
cyclin dependent kinase 5 Inhibitor Inhibition 6.4 pIC50 - 2
pIC50 6.4 (IC50 4x10-7 M) [2]
Description: CDK5(p25)
cyclin dependent kinase 1 Inhibitor Inhibition 6.2 pIC50 - 2
pIC50 6.2 (IC50 6x10-7 M) [2]
Description: CDK1/cyclin B complex
glycogen synthase kinase 3 beta Inhibitor Inhibition 6.0 pIC50 - 2
pIC50 6.0 (IC50 1x10-6 M) [2]