Cdk2 inhibitor IV

Ligand id: 5949

Name: Cdk2 inhibitor IV

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 96.03
Molecular weight 422.24
XLogP 4.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
cyclin dependent kinase 2 Inhibitor Inhibition 6.4 pIC50 - 4
pIC50 6.4 (IC50 4.1x10-7 M) [4]
Description: CDK2/cyclin A complex used in assay
eukaryotic translation initiation factor 2 alpha kinase 2 Inhibitor Inhibition 5.7 pIC50 - 2
pIC50 5.7 (IC50 2x10-6 M) [2]
cyclin dependent kinase 7 Inhibitor Inhibition 5.4 pIC50 - 4
pIC50 5.4 (IC50 3.9x10-6 M) [4]
Description: CDK7/cyclin H complex used in assay
cyclin dependent kinase 4 Inhibitor Inhibition 5.3 pIC50 - 4
pIC50 5.3 (IC50 5.5x10-6 M) [4]
Description: CDK4/cyclin D complex used in assay
cyclin dependent kinase 1 Inhibitor Inhibition 5.2 pIC50 - 4
pIC50 5.2 (IC50 6.6x10-6 M) [4]
Description: CDK1/cyclin B complex used in assay
cyclin dependent kinase 5 Inhibitor Inhibition 4.8 pIC50 - 4
pIC50 4.8 (IC50 1.5x10-5 M) [4]
Description: CDK5/p25 complex used in assay