Cdk4 inhibitor

Ligand id: 5950

Name: Cdk4 inhibitor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 0
Topological polar surface area 77.75
Molecular weight 403
XLogP 3.38
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
cyclin dependent kinase 4 Inhibitor Inhibition 7.1 pIC50 - 3
pIC50 7.1 (IC50 7.6x10-8 M) [3]
Description: CDK4/cyclin D1 complex
cyclin dependent kinase 2 Inhibitor Inhibition 6.3 pIC50 - 3
pIC50 6.3 (IC50 5.2x10-7 M) [3]
Description: CDK2/cyclin E complex
cyclin dependent kinase 1 Inhibitor Inhibition 5.7 pIC50 - 3
pIC50 5.7 (IC50 2.1x10-6 M) [3]
Description: CDK1/cyclin B complex