DNA-PK inhibitor III

Ligand id: 5960

Name: DNA-PK inhibitor III

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 49.77
Molecular weight 221.11
XLogP 0.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at mouse enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
DNA-dependent protein kinase catalytic subunit Inhibitor Inhibition 6.9 pIC50 - 2
pIC50 6.9 (IC50 1.2x10-7 M) [2]
Description: Inhibition of PRKDC in C57BL6 mouse endothelial cells