dovitinib

Ligand id: 5962

Name: dovitinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 85.99
Molecular weight 392.18
XLogP 2.29
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Dovitinib is a reversible ATP-competitive inhibitor of several receptor tyrosine kinases, including VEGFR-2, FGFR-1, and PDGFRβ [4]
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
fms related tyrosine kinase 3 Inhibitor Inhibition 9.2 pKd - 2
pKd 9.2 (Kd 6.4x10-10 M) [2]
fms related tyrosine kinase 3 Inhibitor Inhibition 8.5 – 9.0 pIC50 - 4-5
pIC50 8.5 – 9.0 (IC50 3x10-9 – 1x10-9 M) [4-5]
KIT proto-oncogene receptor tyrosine kinase Inhibitor Inhibition 8.5 – 8.7 pIC50 - 4-5
pIC50 8.5 – 8.7 (IC50 3x10-9 – 2x10-9 M) [4-5]
fms related tyrosine kinase 4 Inhibitor Inhibition 8.1 – 8.5 pIC50 - 4-5
pIC50 8.1 – 8.5 (IC50 8x10-9 – 3x10-9 M) [4-5]
fibroblast growth factor receptor 3 Inhibitor Inhibition 8.1 – 8.5 pIC50 - 4-5
pIC50 8.1 – 8.5 (IC50 9x10-9 – 3x10-9 M) [4-5]
fms related tyrosine kinase 1 Inhibitor Inhibition 8.0 – 8.5 pIC50 - 4-5
pIC50 8.0 – 8.5 (IC50 1x10-8 – 3x10-9 M) [4-5]
fibroblast growth factor receptor 1 Inhibitor Inhibition 8.0 – 8.1 pIC50 - 4-5
pIC50 8.0 – 8.1 (IC50 1.1x10-8 – 8x10-9 M) [4-5]
colony stimulating factor 1 receptor Inhibitor Inhibition 7.4 – 8.5 pIC50 - 4-5
pIC50 7.4 – 8.5 (IC50 3.6x10-8 – 3x10-9 M) [4-5]
platelet derived growth factor receptor beta Inhibitor Inhibition 7.6 – 8.3 pIC50 - 4-5
pIC50 7.6 – 8.3 (IC50 2.7x10-8 – 5x10-9 M) [4-5]
platelet derived growth factor receptor alpha Inhibitor Inhibition 6.7 pIC50 - 5
pIC50 6.7 (IC50 2.1x10-7 M) [5]
epidermal growth factor receptor Inhibitor Inhibition 5.7 pIC50 - 5
pIC50 5.7 (IC50 2x10-6 M) [5]
Insulin receptor Inhibitor Inhibition 5.7 pIC50 - 5
pIC50 5.7 (IC50 2x10-6 M) [5]
kinase insert domain receptor Inhibitor Inhibition - pIC50 - 4-5
pIC50 (IC50 6.5x10-8 – 1.3x10-8 M) [4-5]