EGFR/ErbB-2/ErbB-4 inhibitor

Ligand id: 5965

Name: EGFR/ErbB-2/ErbB-4 inhibitor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 79.8
Molecular weight 355.06
XLogP 3.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
epidermal growth factor receptor Inhibitor Inhibition 9.5 pIC50 - 3
pIC50 9.5 (IC50 3x10-10 M) [3]
erb-b2 receptor tyrosine kinase 4 Inhibitor Inhibition 9.3 pIC50 - 3
pIC50 9.3 (IC50 5x10-10 M) [3]
erb-b2 receptor tyrosine kinase 2 Inhibitor Inhibition 9.0 pIC50 - 3
pIC50 9.0 (IC50 1.1x10-9 M) [3]