(+)-butaclamol

Ligand id: 62

Name: (+)-butaclamol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 23.47
Molecular weight 361.24
XLogP 7.66
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT2A receptor Hs Antagonist Antagonist 8.6 pKi - 1
pKi 8.6 [1]
D2 receptor Hs Antagonist Antagonist 7.5 – 8.7 pKi - 2-4,11
pKi 7.5 – 8.7 [2-4,11]
D5 receptor Hs Antagonist Antagonist 7.6 pKi - 10
pKi 7.6 [10]
5-HT7 receptor Mm Antagonist Antagonist 7.5 pKi - 7
pKi 7.5 [7]
D1 receptor Hs Antagonist Antagonist 6.5 – 8.5 pKi - 10,12
pKi 6.5 – 8.5 [10,12]
D3 receptor Rn Antagonist Antagonist 7.3 – 7.5 pKi - 2
pKi 7.3 – 7.5 [2]
D3 receptor Hs Antagonist Antagonist 6.7 – 8.0 pKi - 3,8,11
pKi 6.7 – 8.0 [3,8,11]
5-HT7 receptor Rn Antagonist Antagonist 7.0 pKi - 9
pKi 7.0 [9]
5-HT1A receptor Hs Antagonist Antagonist 6.4 pKi - 5
pKi 6.4 [5]
D4 receptor Hs Antagonist Antagonist 6.3 pKi - 6
pKi 6.3 [6]