ADX71743

Ligand id: 6217

Name: ADX71743

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 43.1
Molecular weight 269.14
XLogP 5.34
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
ADX71743 exhibits anxiolytic activity in vivo [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mGlu7 receptor Hs Allosteric modulator Negative 7.2 pIC50 - 1
pIC50 7.2 (IC50 6.3x10-8 M) [1]
mGlu7 receptor Rn Allosteric modulator Negative 7.1 pIC50 - 1
pIC50 7.1 (IC50 8.8x10-8 M) [1]