ADX71743

Ligand id: 6217

Name: ADX71743

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 43.1
Molecular weight 269.14
XLogP 5.34
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
ADX71743 exhibits anxiolytic activity in vivo [1].
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mGlu7 receptor Allosteric modulator Negative 7.2 pIC50 - 1
pIC50 7.2 (IC50 6.3x10-8 M) [1]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mGlu7 receptor Allosteric modulator Negative 7.1 pIC50 - 1
pIC50 7.1 (IC50 8.8x10-8 M) [1]