compound 2 [PMID: 21105727]

Ligand id: 6222

Name: compound 2 [PMID: 21105727]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 70.92
Molecular weight 328.06
XLogP 3.34
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mGlu2 receptor Hs Allosteric modulator Negative 6.0 pKi - 1
pKi 6.0 (Ki 1x10-6 M) [1]
mGlu3 receptor Hs Allosteric modulator Positive 4.9 pEC50 - 1
pEC50 4.9 (EC50 1.34x10-5 M) [1]
mGlu2 receptor Hs Allosteric modulator Negative 6.1 pIC50 - 1
pIC50 6.1 (IC50 8x10-7 M) [1]