rivaroxaban

Ligand id: 6388

Name: rivaroxaban

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View more information in the IUPHAR Pharmacology Education Project: rivaroxaban

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 116.42
Molecular weight 435.07
XLogP 1.87
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
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Target Type Action Affinity Units Concentration range (M) Reference
coagulation factor X Inhibitor Inhibition 9.4 pKi - 2
pKi 9.4 (Ki 4x10-10 M) [2]
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Affinity Units Concentration range (M) Reference
andexanet alfa Hs Inhibitor Binding 8.8 pKd - 1
pKd 8.8 (Kd 1.53x10-9 M) [1]
Description: Enzyme assays using purified human plasma fXa, inhibited by rivaroxaban.