compound 41 [PMID: 23434029]

Ligand id: 6420

Name: compound 41 [PMID: 23434029]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 59.81
Molecular weight 324.14
XLogP 4.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mGlu5 receptor Hs Allosteric modulator Negative 7.9 pEC50 - 1
pEC50 7.9 (EC50 1.3x10-8 M) [1]