camostat

Ligand id: 6432

Name: camostat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 137.31
Molecular weight 398.16
XLogP 2.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
This drug inhibits several serine proteases including tyrpsin and prostasin. However, due to a lack of comparative human data we have mapped the reported trypsin inhibition as the likely primary target in pancreatitis.
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
protease, serine 1 Inhibitor Inhibition 7.3 pIC50 - 2
pIC50 7.3 (IC50 5.06x10-8 M) [2]