efalizumab

Ligand id: 6593

Name: efalizumab

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
A peptide BLAST search using the heavy chain peptide sequence of efalizumab identifies sequence ID 5 in patent US6703018 [1] and data is presented from the monoclonal variant designated MHM24 F(ab)-8.
Selectivity at human catalytic receptors
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Target Type Action Affinity Units Concentration range (M) Reference
integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) Antibody Binding 11.4 pKd - 1
pKd 11.4 (Kd 4x10-12 M) [1]
Description: Binding of humanized MHM24 to human CD11a on Jurkat cells.