drotrecogin alfa   Click here for help

GtoPdb Ligand ID: 6788

Synonyms: drotrecogin alfa (activated) | HSDB 7366 | Xigris®
Approved drug
drotrecogin alfa is an approved drug (FDA (2001), EMA (2009))
Comment: Drotrecogin alfa (activated) is a recombinant form of human activated protein C.
Bioactivity Comments
The molecular mechanism is complex and includes inhibition of coagulation factors Va and VIIIa, but we have been unable to find peer reviewed data to substantiate the molecular interaction.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
coagulation factor V Primary target of this compound Hs Inhibitor Inhibition - - - 1-2
Antithrombotic effect thought to occur via inhibition of factors Va and VIIIa [1-2]
coagulation factor VIII Primary target of this compound Hs Inhibitor Inhibition - - - 1-2
Antithrombotic effect thought to occur via inhibition of factors Va and VIIIa [1-2]