chlorpropamide

Ligand id: 6801

Name: chlorpropamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 83.65
Molecular weight 276.03
XLogP 1.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
We have mapped chlorpropamide to SUR1 (ABCC8) as this is the drug's likely molecular target, based on the observations that the pancreatic β-cell ATP-sensitive K+ channel is hetero-octomer of 4 SUR1 subunits and 4 Kir6.2 subunits [1], and that chlorpropamide is a sulfonylurea family drug. We have however, been unable to find affinity data to confirm this proposed interaction.
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Hs Inhibitor Inhibition - - -