hydroxyurea

Ligand id: 6822

Name: hydroxyurea

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 75.35
Molecular weight 76.03
XLogP -1.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
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Target Type Action Affinity Units Concentration range (M) Reference
ribonucleotide reductase catalytic subunit M1 Inhibitor Inhibition 3.8 pIC50 - 1
pIC50 3.8 (IC50 1.48x10-4 M) [1]
Description: Dissolved in 1% DMSO, in vitro assay using reconstituted RRM1/RRM2 holoenzyme
ribonucleotide reductase regulatory subunit M2 Inhibitor Inhibition 3.8 pIC50 - 1
pIC50 3.8 (IC50 1.48x10-4 M) [1]
Description: Dissolved in 1% DMSO, in vitro assay using reconstituted RRM1/RRM2 holoenzyme