pegaptanib   Click here for help

GtoPdb Ligand ID: 6836

Synonyms: EYEOO1 | Macugen® | NX183 | pegaptanib sodium
Approved drug
pegaptanib is an approved drug (FDA (2004), EMA (2006))
Compound class: Synthetic organic
Comment: Pegaptanib is a RNA oligonucleotide aptamer that cts as a vascular endothelial growth factor A antagonist, anti-angiogenic agent.
It is a 28-mer RNA aptamer that is covalently linked to two branched 20-kD polyethylene glycol (PEG) chains.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
VEGFA Primary target of this compound Hs Antagonist Inhibition - - - 1-2
[1-2]