repaglinide

Ligand id: 6841

Name: repaglinide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 78.87
Molecular weight 452.27
XLogP 6.09
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
As we are unable to identify which subunit of the sulfonylurea receptor/potassium channel the drug binds, we have not tagged a primary drug target.
Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Inhibitor Inhibition 7.0 pIC50 - 1
pIC50 7.0 (IC50 1.06x10-7 M) [1]