tolbutamide

Ligand id: 6848

Name: tolbutamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 83.65
Molecular weight 270.1
XLogP 2.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Kir6.2 Rn Channel blocker Antagonist - - 5x10-4 2
Conc range: 5x10-4 M [2]
Voltage: -60.0 mV
Kir6.2 Mm Channel blocker Antagonist 4.5 pIC50 - 1
pIC50 4.5 [1]
Voltage: Physiological
Kir6.1 Hs Inhibitor - - - -
Kir6.2 Hs Inhibitor - - - -