tazarotene

Ligand id: 6952

Name: tazarotene

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 64.49
Molecular weight 351.13
XLogP 6.22
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Tazarotene appears to have highest affinity for the retinoic acid receptor-β [1].
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Retinoic acid receptor-β Agonist Agonist 9.1 pEC50 - 1
pEC50 9.1 (EC50 8x10-10 M) [1]
Retinoic acid receptor-γ Agonist Agonist 7.4 pEC50 - 1
pEC50 7.4 (EC50 4x10-8 M) [1]
Retinoic acid receptor-α Agonist Agonist 7.2 pEC50 - 1
pEC50 7.2 (EC50 6.3x10-8 M) [1]