adrenomedullin   Click here for help

GtoPdb Ligand ID: 697

Abbreviated name: AM
Species: Rat
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Natural/Endogenous Targets
Target
ACKR3
AM1 receptor
AM2 receptor
CGRP receptor
GPR182
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPR182 Ligand is endogenous in the given species Rn Agonist Partial agonist 8.1 pEC50 - 5
pEC50 8.1 (EC50 7x10-9 M) [5]
ACKR3 Ligand is endogenous in the given species Rn Agonist Agonist 7.0 pEC50 - 6
pEC50 7.0 (EC50 1x10-7 M) Dose dependant increase of cAMP [6]
AM1 receptor Ligand is endogenous in the given species Rn Agonist Full agonist 8.7 – 9.3 pIC50 - 1-2,4,7
pIC50 8.7 – 9.3 [1-2,4,7]
AM2 receptor Mm Agonist Full agonist 8.2 pIC50 - 3
pIC50 8.2 [3]
AM2 receptor Ligand is endogenous in the given species Rn Agonist Full agonist 8.2 pIC50 - 4
pIC50 8.2 [4]
AM1 receptor Mm Agonist Full agonist 8.0 pIC50 - 3
pIC50 8.0 [3]
CGRP receptor Ligand is endogenous in the given species Rn Agonist Full agonist 6.8 – 8.8 pIC50 - 4,7
pIC50 6.8 – 8.8 [4,7]
CGRP receptor Mm Agonist Full agonist 7.6 pIC50 - 3
pIC50 7.6 [3]