amlodipine

Ligand id: 6981

Name: amlodipine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 99.88
Molecular weight 408.15
XLogP 3.25
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Due to the complex nature of this drug's MMOA, and the paucity of (human) affinity data, we do not tag a primary drug target.

Amlodipine has been described as a gating modifier of Cav channels [1].
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Cav1.3 Gating inhibitor Inhibition 7.2 pIC50 - 2
pIC50 7.2 (IC50 6.01x10-8 M) [2]
Description: Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells