AZ505

Ligand id: 7021

Name: AZ505

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 14
Topological polar surface area 102.93
Molecular weight 576.23
XLogP 3.93
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
AZ505 inhibits SMYD2 but not several other methyltransferases tested [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
SET and MYND domain containing 2 Inhibitor Inhibition 6.9 pIC50 - 1
pIC50 6.9 (IC50 1.2x10-7 M) [1]