methylprednisolone

Ligand id: 7088

Name: methylprednisolone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.83
Molecular weight 374.21
XLogP 1.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPC5 Hs Activator Activation 4.9 pEC50 - 2
pEC50 4.9 (EC50 1.2x10-5 M) [2]
Description: Measuring intracellular calcium elevation in HEK293 cells expressing hTRPC5.
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Glucocorticoid receptor Hs Agonist Agonist 8.3 pKi - 1
pKi 8.3 (Ki 5.03x10-9 M) [1]