cilostazol

Ligand id: 7148

Name: cilostazol

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: cilostazol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 81.93
Molecular weight 369.22
XLogP 3.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Cilostazol has also been reported to promote the clearance of fluorescent soluble amyloid β tracers in cilostazol-treated cerebral amyloid angiopathy (CAA) model mice, by enhancing the perivascular drainage system [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
phosphodiesterase 3A Inhibitor Inhibition 6.7 pIC50 - 2
pIC50 6.7 (IC50 2x10-7 M) [2]
phosphodiesterase 3B Inhibitor Inhibition 6.4 pIC50 - 2
pIC50 6.4 (IC50 3.8x10-7 M) [2]