fenofibrate

Ligand id: 7186

Name: fenofibrate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 52.6
Molecular weight 360.11
XLogP 5.29
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Bioactivity resides with the active metabolite.
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Peroxisome proliferator-activated receptor-α Agonist Agonist 4.5 pEC50 - 2
pEC50 4.5 (EC50 3x10-5 M) [2]
Description: In a cell based hPPAR-GAL4 transactivation assay.
Selectivity at rat other protein targets
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
fatty acid binding protein 1 Inhibitor Inhibition 7.6 pKi - 1
pKi 7.6 (Ki 2.4x10-8 M) [1]