Ligand Id: 720
Ligand name L-alanine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 63.32
Molecular weight 89.05
XLogP -2.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands Radio analogues
Transporters
Transporter DB page EC number Reaction Reference
Proton-coupled Amino acid Transporter 1 View in GRAC
Proton-coupled Amino acid Transporter 2 View in GRAC
B0AT2 View in GRAC 8
NTT4 View in GRAC 7
SNAT3 View in GRAC 10
SNAT4 View in GRAC 5
Alanine/serine/cysteine transporter 2 View in GRAC
B0AT1 View in GRAC 8
SNAT2 View in GRAC 3
Alanine/serine/cysteine transporter 1 View in GRAC
SNAT5 View in GRAC 4
SNAT1 View in GRAC 6
B0AT3 View in GRAC 9

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Rank order of potency at human receptors (unless otherwise stated)
Description Rank order of potency Reference
Endogenous substrates at Alanine/serine/cysteine transporter 1 L-cysteine > L-alanine = L-serine > L-threonine
Endogenous substrates at Alanine/serine/cysteine transporter 2 L-alanine = L-serine = L-cysteine (low Vmax) = L-threonine = L-glutamine = L-asparagine >> L-methionine ≅ glycine ≅ L-leucine > L-valine > L-glutamic acid (enhanced at low pH)
Endogenous substrates at B0AT1 L-leucine, L-methionine, L-isoleucine, L-valine > L-asparagine, L-phenylalanine, L-alanine, L-serine > L-threonine, glycine, L-proline 8
Endogenous substrates at B0AT2 L-proline > L-alanine, L-valine, L-methionine, L-leucine > L-isoleucine, L-threonine, L-asparagine, L-serine, L-phenylalanine > glycine 8
Endogenous substrates at B0AT3 L-alanine, glycine > L-methionine, L-phenylalanine, L-leucine, L-histidine, L-glutamine 9
Endogenous substrates at NTT4 L-leucine, L-methionine, L-proline > L-cysteine, L-alanine, L-glutamine, L-serine > L-histidine, glycine 7
Substrates at SNAT2 L-alanine, L-methionine > L-asparagine, L-glutamine, L-serine, L-proline, glycine > L-threonine, L-leucine, L-phenylalanine 3
Substrates at SNAT4 L-histidine > L-arginine, L-alanine, L-asparagine, L-lysine > glycine, L-glutamine, L-serine, L-proline, L-leucine, L-phenylalanine 5
Substrates at SNAT3 L-histidine , L-glutamine > L-asparagine, L-alanine > L-glutamic acid 10
Substrates at SNAT5 L-asparagine, L-serine, L-histidine, L-glutamine > glycine, L-alanine 4
Substrates at SNAT1 L-alanine > L-serine, L-glutamine, L-asparagine, L-histidine, L-cysteine, L-methionine > glycine, L-threonine, L-proline, L-tyrosine, L-valine 6
Amino-acid rank order of potency at CaS receptor L-phenylalanine, L-tryptophan, L-histidine > L-alanine > L-serine, L-proline, L-glutamic acid > L-aspartic acid (not L-lysine, L-arginine, L-leucine and L-isoleucine) 2

Selectivity data from IUPHAR-DB

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
GPRC6 receptor Agonist Full agonist 3.8 pEC50 - 1

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org