mesoridazine

Ligand id: 7227

Name: mesoridazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 68.06
Molecular weight 386.15
XLogP 3.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Note that the affinity values in the table below were produced using a specific stereoisomer of the mesoridazine, referred to as isomer 2 in [1] (which has IUPAC name 2-[(R)-methanesulfinyl]-10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-10H-phenothiazine).
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
D2 receptor Hs Antagonist Antagonist 8.7 pKi - 1
pKi 8.7 (Ki 2.2x10-9 M) [1]
D3 receptor Hs Antagonist Antagonist 7.6 pKi - 1
pKi 7.6 (Ki 2.3x10-8 M) [1]
5-HT2A receptor Hs Antagonist Antagonist 7.3 pKi - 1
pKi 7.3 (Ki 5.5x10-8 M) [1]
D1 receptor Hs Antagonist Antagonist 7.0 pKi - 1
pKi 7.0 (Ki 1.03x10-7 M) [1]
5-HT1A receptor Hs Antagonist Antagonist 7.0 pKi - 1
pKi 7.0 (Ki 1.05x10-7 M) [1]
5-HT2C receptor Hs Antagonist Antagonist 6.4 pKi - 1
pKi 6.4 (Ki 4.12x10-7 M) [1]