mitoxantrone

Ligand id: 7242

Name: mitoxantrone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 8
Rotatable bonds 12
Topological polar surface area 163.18
Molecular weight 444.2
XLogP -2.17
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have been unable to find publicly available affinity data for this drug at its proposed molecular target(s) to substantiate its MMOA, and have therefore not tagged a primary drug target.
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
DNA topoisomerase II alpha Inhibitor Inhibition 5.3 pIC50 - 1
pIC50 5.3 (IC50 5.3x10-6 M) [1]
Description: Inhibition of topoisomerase IIα-mediated decatenation activity.