prochlorperazine

Ligand id: 7279

Name: prochlorperazine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 35.02
Molecular weight 373.14
XLogP 4.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Prochlorperazine has selective affinity for the dopamine 2-like receptors, with highest affinity for the D2 and D3 receptors. The drug's affinity for the D4 receptor is significantly lower.
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
D2 receptor Antagonist Antagonist 8.4 pKi - 1
pKi 8.4 (Ki 3.61x10-9 M) [1]
D3 receptor Antagonist Antagonist 8.4 pKi - 1
pKi 8.4 (Ki 4.45x10-9 M) [1]
D1 receptor Antagonist Antagonist 7.1 pKi - 1
pKi 7.1 (Ki 7.8x10-8 M) [1]
D4 receptor Antagonist Antagonist 6.1 pKi - 1
pKi 6.1 (Ki 8.1x10-7 M) [1]