promazine

Ligand id: 7281

Name: promazine

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View more information in the IUPHAR Pharmacology Education Project: promazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 31.78
Molecular weight 284.13
XLogP 4.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have tagged interactions with the dopamine D2 and D3 as primary drug targets for promazine. Note however that this drug is also proposed to interact with the 5-HT2a receptor, although we have been unable to find affinity data for the human receptor to substantiate this.
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
D3 receptor Antagonist Antagonist 6.8 pKi - 1
pKi 6.8 (Ki 1.59x10-7 M) [1]
D2 receptor Antagonist Antagonist 6.5 pKi - 1
pKi 6.5 (Ki 3x10-7 M) [1]