tizanidine   Click here for help

GtoPdb Ligand ID: 7308

Synonyms: AN-021 | DS-103-282 | Zanaflex®
Approved drug
tizanidine is an approved drug (FDA (1996))
Compound class: Synthetic organic
Comment: Tizanidine is a centrally acting α2-adrenoceptor agonist.
Marketed formulations may contain tizanidine hydrochloride (PubChem CID 114869).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: tizanidine

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 90.44
Molecular weight 253.02
XLogP 2.25
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Clc1ccc2c(c1NC1=NCCN1)nsn2
Isomeric SMILES Clc1ccc2c(c1NC1=NCCN1)nsn2
InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
InChI Key XFYDIVBRZNQMJC-UHFFFAOYSA-N
Bioactivity Comments
As we have been unable to find publicly available affinity data for this drug (at the human target) to substantiate its MMOA, we have not mapped a primary drug target in this case.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
α2A-adrenoceptor Hs Agonist Agonist 6.0 pKi - 3
⤷ pKi 6.0 [3]
α2B-adrenoceptor Hs Agonist Agonist 5.8 pKi - 3
⤷ pKi 5.8 [3]
α2A-adrenoceptor Hs Agonist Agonist 5.8 – 8.4 pEC50 - 3
⤷ pEC50 8.4 [3]
Description: increased ERK1/2 phosphorylation
pEC50 5.8 [3]
Description: increased cAMP generation
α2B-adrenoceptor Hs Agonist Agonist 6.3 – 7.0 pEC50 - 3
⤷ pEC50 7.0 [3]
Description: ERK1/2 phosphorylation
pEC50 6.3 [3]
Description: cAMP generation
α2B-adrenoceptor Hs Agonist Agonist 7.8 pIC50 - 3
⤷ pIC50 7.8 [3]
Description: inhibition of forskolin stimulated cAMP generation
α2A-adrenoceptor Hs Agonist Agonist 7.6 pIC50 - 3
⤷ pIC50 7.6 [3]
Description: inhibition of forskolin stimulated cAMP generation