tolazoline

Ligand id: 7310

Name: tolazoline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 24.39
Molecular weight 160.1
XLogP 3.13
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In vitro experiments have shown that tolazoline inhibits noradrenaline-induced contraction of isolated radial arteries from human patients with a pEC50 of 5.4 [2].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
α2A-adrenoceptor Hs Antagonist Antagonist 7.6 pKi - 1
pKi 7.6 (Ki 2.29x10-7 M) [1]
Description: Inhibition of agonist-stimulated [35S]GTPγS binding
α2B-adrenoceptor Hs Antagonist Antagonist 5.5 pKi - 1
pKi 5.5 (Ki 3.162x10-6 M) [1]
Description: Inhibition of agonist-stimulated [35S]GTPγS binding
α2C-adrenoceptor Hs Antagonist Antagonist 5.4 pKi - 1
pKi 5.4 (Ki 3.715x10-6 M) [1]
Description: Inhibition of agonist-stimulated [35S]GTPγS binding