tolazoline

Ligand id: 7310

Name: tolazoline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 24.39
Molecular weight 160.1
XLogP 3.13
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In vitro experiments have shown that tolazoline inhibits noradrenaline-induced contraction of isolated radial arteries from human patients with a pEC50 of 5.4 [2].
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
α2A-adrenoceptor Antagonist Antagonist 7.6 pKi - 1
pKi 7.6 (Ki 2.29x10-7 M) [1]
Description: Inhibition of agonist-stimulated [35S]GTPγS binding
α2B-adrenoceptor Antagonist Antagonist 5.5 pKi - 1
pKi 5.5 (Ki 3.162x10-6 M) [1]
Description: Inhibition of agonist-stimulated [35S]GTPγS binding
α2C-adrenoceptor Antagonist Antagonist 5.4 pKi - 1
pKi 5.4 (Ki 3.715x10-6 M) [1]
Description: Inhibition of agonist-stimulated [35S]GTPγS binding