compound 24 [PMID: 16451050]

Ligand id: 7361

Name: compound 24 [PMID: 16451050]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 44.81
Molecular weight 433.27
XLogP 5.49
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
NOP receptor Antagonist Antagonist 9.6 pKi - 1
pKi 9.6 (Ki 2.4x10-10 M) [1]
NOP receptor Antagonist Antagonist 9.6 – 10.0 pIC50 - 1-2
pIC50 9.6 – 10.0 (IC50 2.7x10-10 – 1x10-10 M) [1-2]