tasimelteon

Ligand id: 7393

Name: tasimelteon

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 38.33
Molecular weight 245.14
XLogP 2.45
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Tasimelteon is a non-selective MT1/MT2 receptor ligand, with low nanomolar affinities for the human receptors.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
MT2 receptor Hs Agonist Full agonist 10.2 pKi - 1
pKi 10.2 (Ki 6.92x10-11 M) [1]
MT1 receptor Hs Agonist Full agonist 9.5 pKi - 1
pKi 9.5 (Ki 3.04x10-10 M) [1]