Synonyms: compound 3 [PMID: 8863805] [1] | RP-27267 | Zimovane®
zopiclone is an approved drug
Compound class:
Synthetic organic
Comment: Zopiclone is a racemic mixture of the R and S chemical stereoisomers (PubChem CID 941731 and eszopiclone respectively). Eszopiclone is an approved drug in its own right.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: zopiclone |
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Bioactivity Comments |
Due to the complex and varied nature of the precise subunit composition of GABAA channels, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug. Data from experiments using central benzodiazepine receptors isolated from synaptosomal membranes of rat cerebral cortex, in a competition binding assay with [3H]flunitrazepam, provide a zopiclone IC50 of 29 nM [1]. |