rufinamide

Ligand id: 7470

Name: rufinamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 73.8
Molecular weight 238.07
XLogP 0.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Rodent studies show that rufinamide (1μM) significantly slows sodium channel recovery from inactivation in cultured cortical neurons from immature rats and that the drug limits sustained repetitive firing of sodium-dependent action potentials, with an EC50 of 3.8μM [1].
However, we have been unable to find publicly available bioactivity data for this drug at its proposed human molecular target(s) to substantiate its MMOA, and have therefore not tagged a primary drug target.