lacosamide

Ligand id: 7472

Name: lacosamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 67.43
Molecular weight 250.13
XLogP 1.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have tagged the Nav1.7 voltage-gated sodium channel as the primary target of this drug, simply as this is the only human voltage-gated sodium channel for which we have been able to find affinity data. This does not preclude interaction at other sodium channels.
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Nav1.7 Channel blocker Antagonist 3.7 pIC50 - 3
pIC50 3.7 (IC50 1.82x10-4 M) [3]
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Nav1.8 Channel blocker Antagonist 4.8 pIC50 - 3
pIC50 4.8 (IC50 1.6x10-5 M) [3]
Nav1.2 Channel blocker Antagonist 4.5 pIC50 - 1
pIC50 4.5 (IC50 3x10-5 M) [1]
Voltage: -80.0 mV
Nav1.3 Channel blocker Antagonist 3.4 pIC50 - 3
pIC50 3.4 (IC50 4.15x10-4 M) [3]