panobinostat

Ligand id: 7489

Name: panobinostat

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: panobinostat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 4
Rotatable bonds 8
Topological polar surface area 77.15
Molecular weight 349.18
XLogP 4.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
histone deacetylase 2 Inhibitor Inhibition 8.5 pEC50 - 1
pEC50 8.5 (EC50 3x10-9 M) [1]
histone deacetylase 9 Inhibitor Inhibition 8.5 pEC50 - 1
pEC50 8.5 (EC50 3x10-9 M) [1]
histone deacetylase 1 Inhibitor Inhibition 8.5 pEC50 - 1
pEC50 8.5 (EC50 3x10-9 M) [1]
histone deacetylase 3 Inhibitor Inhibition 8.4 pEC50 - 1
pEC50 8.4 (EC50 4x10-9 M) [1]
histone deacetylase 4 Inhibitor Inhibition 7.9 pEC50 - 1
pEC50 7.9 (EC50 1.2x10-8 M) [1]
histone deacetylase 7 Inhibitor Inhibition 7.8 pEC50 - 1
pEC50 7.8 (EC50 1.4x10-8 M) [1]
histone deacetylase 6 Inhibitor Inhibition 7.2 pEC50 - 1
pEC50 7.2 (EC50 6.1x10-8 M) [1]
histone deacetylase 8 Inhibitor Inhibition 6.6 pEC50 - 1
pEC50 6.6 (EC50 2.48x10-7 M) [1]
Ligand mentioned in the following text fields